The copper-zinc superoxide dismutase activity in selected diseases.
Łukasz LewandowskiMarta KepinskaHalina MilnerowiczPublished in: European journal of clinical investigation (2018)
Copper-zinc superoxide dismutase (Cu,Zn-SOD) plays a protective role in various types of tissue protecting them from oxidative damage. Alterations in Cu,Zn-SOD (SOD1 and SOD3) activity and its expression have been observed in pathological occurrences most prevalent in modern society, including inflammatory bowel disease, obesity and its implications-diabetes and hypertension, and chronic obstructive pulmonary disease. Moreover, several SOD1 and SOD3 gene polymorphisms have been associated with the risk of developing a particular type of disease, or its exacerbation. This article features recent observations in this topic, aiming to show the importance of proper gene sequence and activity of Cu,Zn-SOD in the aforementioned diseases.
Keyphrases
- amyotrophic lateral sclerosis
- chronic obstructive pulmonary disease
- type diabetes
- oxide nanoparticles
- heavy metals
- blood pressure
- cardiovascular disease
- insulin resistance
- poor prognosis
- metabolic syndrome
- weight loss
- hydrogen peroxide
- intensive care unit
- cystic fibrosis
- lung function
- dna methylation
- glycemic control
- nitric oxide
- air pollution
- amino acid