Abdominal inflammatory myofibroblastic tumour: Clinicopathological and molecular analysis of 20 cases, highlighting potential therapeutic targets.
Astrid I P VernemmenIryna V SamarskaErnst-Jan M SpeelRobert G RiedlDanny GoudkadeAdriaan P de BruïneSiep WoudaArienne M van MarionIvana V VerlindenIneke van LijnschotenPieter FriederichVéronique J L WinnepenninckxAxel Zur HausenRaf M E SciotMari F C M van den HoutPublished in: Histopathology (2023)
This study shows the wide clinical spectrum of abdominal IMTs and affirms the poor prognosis of EIMS, raising discussion about its status as IMT subtype. Furthermore, the newly detected alterations of the RTK/PI3K/AKT pathway expand the molecular landscape of IMTs and provide potential therapeutic targets.