Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1.
Junhan ChenShin-Ichi IkedaYajing YangYan ZhangZiyan MaYifan LiangKazuno NegishiKazuo TsubotaToshihide KuriharaPublished in: Molecular medicine (Cambridge, Mass.) (2024)
Our findings indicate that sclera THBS1 levels decreased during myopia development and subsequent THBS1 knockdown showed a decrease in scleral COLA1 expression. Taken together, these results suggest that THBS1 plays a role in maintaining the homeostasis of scleral extracellular matrix, and the reduction of THBS1 may promote the remodeling process and then affect ocular axial elongation during myopia progression.