ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy Utilization.

Grazia Pennisi Samantha Maurotti Ester CiociolaOveis JamialahmadiGiorgio Bertolazzi Angela Mirarchi Per-Olof Bergh Francesca Scionti Rosellina Margherita Mancina Rocco Spagnuolo Claudio TripodoJan BorenSalvatore Petta Stefano Romeo

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

downregulation by silencing RNA led to an increase in triglycerides content due to a reduction in energy substrate utilization resembling a primary intracellular hepatocyte hypothyroidism.

Keyphrases

cell proliferation
signaling pathway
reactive oxygen species
liver injury
fatty acid
replacement therapy
drug induced