The role of DNA demethylation in liver to pancreas transdifferentiation.

Adi Har-ZahavDaniela LixandruDavid CheishviliIoan Valentin MateiIoana Raluca FloreaVeronica Madalina AspritoiuInna Blus-KadoshIrit Meivar-LevyAndreea Madalina SerbanIrinel PopescuMoshe SzyfSarah FerberSimona Olimpia Dima

Published in: Stem cell research & therapy (2022)

Transdifferentiation is associated with global DNA hypomethylation, and with increased expression of specific demethylated genes. A combination of epigenetic modulators may be used to increase chromatin accessibility of the pancreatic transcription factors, thus promoting the efficiency of the developmental process.

Keyphrases

transcription factor
circulating tumor
cell free
genome wide
single molecule
gene expression
poor prognosis
dna methylation
genome wide identification
small molecule
dna damage
nucleic acid
circulating tumor cells
binding protein
oxidative stress
bioinformatics analysis