Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors.
Yuxin ChenXiaohuan LiQian XiongYehong DuMan LuoLilin YiYayan PangXiuyu ShiYu Tian WangZhifang DongPublished in: Journal of translational medicine (2023)
Inhibiting the NLRP3 inflammasome signaling pathway promotes neurological recovery in animals with HIBD by increasing p97-mediated surface GluA1 expression, thereby providing new insight into HIE therapy.
Keyphrases
- nlrp inflammasome
- signaling pathway
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- cerebral ischemia
- poor prognosis
- white matter
- stem cells
- resting state
- multiple sclerosis
- cell proliferation
- binding protein
- blood brain barrier
- endoplasmic reticulum stress
- functional connectivity
- bone marrow
- cell therapy