Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids.

Wenyi ChenJiaqi ZhuFeiyan LinYanping XuBing FengXudong FengXinyu ShengXiaowei ShiQiaoling PanJinfeng YangJiong YuLanjuan LiHongcui Cao

Published in: Stem cell research & therapy (2021)

Senescent organoids are a potential novel model for better understanding senescence progression in cholangiocytes. hPMSC-derived exosomes exert protective effects against senescent cholangioids under oxidative stress-induced injury by delaying aging and reducing SASP components, which might have therapeutic potential for PSC or PBC.

Keyphrases

mesenchymal stem cells
endothelial cells
high glucose
umbilical cord
stem cells
induced pluripotent stem cells
bone marrow
dna damage
diabetic rats
cell therapy
stress induced
pluripotent stem cells
oxidative stress
human health