TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.
Edgar Gonzalez-BuendiaJunfei ZhaoLu WangSubhas MukherjeeDaniel Yang ZhangVíctor A ArrietaEric FeldsteinJ Robert KaneSeong Jae KangCatalina Lee-ChangAayushi MahajanLi ChenRonald RealubitCharles KaranLisa MagnusonCraig HorbinskiStacy A MarshallJann N SarkariaAhmed MohyeldinIchiro NakanoMukesh BansalCharles D JamesDaniel J BratAtique U AhmedPeter CanollRaul RabadanAli ShilatifardAdam M SonabendPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our results indicate that TOP2B activity exerts a pleiotropic role in transcriptional regulation of oncogenes in a subset of gliomas promoting a proliferative phenotype.