Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults.
Mark James PonsfordRhys JefferiesChris DaviesDaniel FarewellIan R HumphreysStephen JollesSara FairbairnKeir LewisDaniel MenziesAmit BenjaminFavas ThaivalappilChris WilliamsSimon M BarryPublished in: Thorax (2021)
The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%-35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21-63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures.
Keyphrases
- sars cov
- healthcare
- mental health
- acinetobacter baumannii
- methicillin resistant staphylococcus aureus
- respiratory syndrome coronavirus
- physical activity
- klebsiella pneumoniae
- emergency department
- cross sectional
- staphylococcus aureus
- study protocol
- palliative care
- cardiovascular events
- cardiovascular disease
- pseudomonas aeruginosa
- electronic health record
- double blind