The clinicopathological and molecular analysis of gastric cancer with altered SMARCA4 expression.
Shih-Chiang HuangKwai-Fong NgTa-Sen YehChi-Tung ChengMin-Chi ChenYi-Chun ChaoHuei-Chieh ChuangYu-Jen LiuTse-Ching ChenPublished in: Histopathology (2020)
SMARCA4-altered GCs are rare and have intratumoral heterogeneity, histomorphological diversity, conditional prognostic significance and various genetic drivers. SMARCA4-lost GC may represent a genuine SMARCA4-deficient neoplasm, but most SMARCA4-reduced/heterogeneous cases are secondary to ARID1A collapse or associated with different genotypes.