A self-powered intracardiac pacemaker in swine model.
Zhuo LiuYiran HuXuecheng QuYing LiuSijing ChengZhengmin ZhangYizhu ShanRuizeng LuoSixian WengHui LiHongxia NiuMin GuYan YaoBojing ShiNingning WangWei HuaZhou LiZhong Lin WangPublished in: Nature communications (2024)
Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction for the treatment of arrhythmia in large animal models. We show that the capsule-shaped device (1.75 g, 1.52 cc) can be integrated with a delivery catheter for implanting in the right ventricle of a swine through the intravenous route, which effectively converts cardiac motion energy to electricity and maintains endocardial pacing function during the three-week follow-up period. We measure in vivo open circuit voltage and short circuit current of the self-powered intracardiac pacemaker of about 6.0 V and 0.2 μA, respectively. This approach exhibits up-to-date progress in self-powered medical devices and it may overcome the inherent energy shortcomings of implantable pacemakers and other bioelectronic devices for therapy and sensing.
Keyphrases
- left atrial appendage
- vena cava
- left ventricular
- cardiac resynchronization therapy
- pulmonary hypertension
- minimally invasive
- pulmonary artery
- mitral valve
- randomized controlled trial
- heart failure
- high speed
- molecular dynamics simulations
- ultrasound guided
- pulmonary arterial hypertension
- combination therapy
- cell therapy
- energy transfer
- quantum dots