Role of extracellular LncRNA-SNHG14/miRNA-3940-5p/NAP12 mRNA in colorectal cancer.

Marwa MatboliAyman E ShafeiMahmoud A AliTarek Salah El-Din AhmedMahmoud NaserTamer Abdel-RahmanNahla AnberMarwa Ali

Published in: Archives of physiology and biochemistry (2019)

The extracellular lncRNA SNHG14- hsa-miR-3940-5p - NAP1L2 mRNA may aid in CRC management.KEY MESSAGESThe extracellular RNAs provide a potential class of noninvasive biomarkers with high specificity, accuracy and stability for detection of CRC.We used insilico data analysis followed by qPCR for detection of differential NAP1L2 gene expression with the selected epigenetic regulators.Our data presented interesting biomarker panel (NAP1L2 gene, lncRNA-SNHG14 and hsa-miR-3940-5p) that may be potential for CRC diagnosis and prognosis.

Keyphrases

data analysis
gene expression
poor prognosis
long non coding rna
dna methylation
loop mediated isothermal amplification
long noncoding rna
label free
real time pcr
genome wide
human health
transcription factor
electronic health record
risk assessment
deep learning