Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves.
Qunzhou ZhangJustin C BurrellJincheng ZengFaizan I MotiwalaShihong ShiD Kacy CullenAnh D LePublished in: Stem cell research & therapy (2022)
Collectively, these findings suggest that Schwann-like cells converted from GMSCs represent a promising source of supportive cells for regenerative therapy of PNI through their dual functions, neurotrophic effects, and immunomodulation of pro-inflammatory (M1)/pro-regenerative (M2) macrophages.
Keyphrases
- peripheral nerve
- stem cells
- cell therapy
- mesenchymal stem cells
- induced apoptosis
- endothelial cells
- cell cycle arrest
- tissue engineering
- oxidative stress
- induced pluripotent stem cells
- anti inflammatory
- neuropathic pain
- pluripotent stem cells
- endoplasmic reticulum stress
- spinal cord
- spinal cord injury
- optic nerve
- replacement therapy
- optical coherence tomography