Biomolecular Condensation: A New Phase in Cancer Research.
Anupam K ChakravartyDaniel J McGrailThomas M LozanoskiBrandon S DunnDavid J H ShihKara M CirilloSueda H CetinkayaWenjin Jim ZhengGordon B MillsS Stephen YiDaniel F JaroszNidhi SahniPublished in: Cancer discovery (2022)
One of the fundamental functions of phase separation is to rapidly and dynamically respond to environmental perturbations. Importantly, these changes often lead to alterations in cancer-relevant pathways and processes. This review covers recent advances in the field, including emerging principles and mechanisms of phase separation in cancer.