Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.

Liqun YangQian LeiLin LiJie YangZhen DongHong-Juan Cui

Published in: Clinical epigenetics (2019)

Our results show that DOT1L epigenetically promotes the transcription of c-Myc via H3K79me2. DOT1L silencing or inhibition induces cell cycle arrest at S phase. DOT1L is a potential marker for colorectal cancer and EPZ004777 may be a potential drug for the treatment of colorectal cancer.

Keyphrases

cell cycle arrest
cell death
pi k akt
energy transfer
signaling pathway
poor prognosis
long noncoding rna
human health
cell proliferation
risk assessment
climate change
quantum dots
drug induced