Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.
Huixin XuEilrayna GelyanaMolly RajsombathTing YangShaomin LiDennis SelkoePublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
Environmental enrichment (EE) is a potential therapy to delay Alzheimer's disease (AD). Microglial inflammation is associated with the progression of AD, but the influence of EE on microglial inflammation is unclear. Here we systematically applied in vivo methods to show that EE alters microglia in the dentate gyrus under physiological conditions and robustly prevents microglial inflammation induced by human Aβ oligomers, as shown by neutralized microglial inflammatory morphology, mRNA changes, and brain interstitial fluid cytokine levels. Our findings suggest that EE alters the innate immune system and could serve as a therapeutic approach to AD and provide new targets for drug discovery. Further, we propose that the therapeutic benefits of EE could extend to other neurodegenerative diseases involving microglial inflammation.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- oxidative stress
- lps induced
- neuropathic pain
- drug discovery
- endothelial cells
- immune response
- spinal cord
- induced pluripotent stem cells
- human health
- stem cells
- pluripotent stem cells
- cognitive decline
- risk assessment
- binding protein
- white matter
- amino acid
- life cycle
- blood brain barrier
- cell therapy
- mild cognitive impairment