The relationship between pancreas steatosis and the risk of metabolic syndrome and insulin resistance in Chinese adolescents with concurrent obesity and non-alcoholic fatty liver disease.
Winnie Chiu Wing ChuDorothy F Y ChanSteve C N HuiHung-Kwan SoMin DengDavid K W YeungE Anthony S NelsonChiu-Wing Winnie ChuPublished in: Pediatric obesity (2020)
Fatty pancreas is a common finding in adolescents with obesity, with a prevalence rate of 50% in this study cohort. Liver PDFF and VAT are independent predictors of insulin resistance while pancreas PDFF and liver PDFF are independent predictors of both beta cells dysfunction and metabolic syndrome. Presence of fatty pancreas at imaging should not be considered as a benign finding but rather as an imaging biomarker of emerging pancreatic metabolic and endocrine dysfunction.
Keyphrases
- insulin resistance
- metabolic syndrome
- high fat diet induced
- high fat diet
- young adults
- adipose tissue
- polycystic ovary syndrome
- skeletal muscle
- type diabetes
- high resolution
- uric acid
- oxidative stress
- induced apoptosis
- physical activity
- cardiovascular risk factors
- risk factors
- weight loss
- fatty acid
- glycemic control
- cell cycle arrest
- cell death
- liver fibrosis
- cardiovascular disease
- endoplasmic reticulum stress
- signaling pathway
- weight gain
- body mass index
- fluorescence imaging
- locally advanced
- cell proliferation