Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro.

Célia FourrierJulie Remus-BorelAndrew D GreenhalghMichel GuichardantNathalie Bernoud-HubacMichel LagardeCorinne JoffreSophie Layé

Published in: Journal of neuroinflammation (2017)

These results highlight the potency of administered DHA-acetylated to phospholipids-to rapidly regulate LPS-induced neuroinflammatory processes through their effect on microglia. In particular, both IL-6 production and signaling are targeted by AceDoPC in microglia.

Keyphrases

lps induced
inflammatory response
fatty acid
lipopolysaccharide induced
neuropathic pain
spinal cord
drug delivery