Protective Effects of Diallyl Sulfide Against Ethanol-Induced Injury in Rat Adipose Tissue and Primary Human Adipocytes.
Venkata Harini KemaImran KhanReshma JamalSandeep Kumar VishwakarmaChandrakala Lakki ReddyKirti ParwaniFarhin PatelDhara PatelAleem A KhanPalash MandalPublished in: Alcoholism, clinical and experimental research (2017)
Our study results prove that DAS is effective in ameliorating EtOH-induced damage to adipose tissue as evidenced by the reduction brought about by DAS in oxidative stress, ER stress, and proinflammatory gene expression levels. DAS treatment also regulated lipogenic gene expression levels, thereby reducing free fatty acid release. In conclusion, this study has clinical implications with respect to alcohol-induced adipose tissue injury among alcohol users.
Keyphrases
- adipose tissue
- gene expression
- oxidative stress
- diabetic rats
- high glucose
- insulin resistance
- endothelial cells
- high fat diet
- disease activity
- fatty acid
- dna methylation
- drug induced
- type diabetes
- rheumatoid arthritis
- dna damage
- metabolic syndrome
- transcription factor
- ischemia reperfusion injury
- skeletal muscle
- signaling pathway
- induced apoptosis
- induced pluripotent stem cells