How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks: post-hoc analysis of TRUFFLE study.
Wessel J GanzevoortN Mensing Van CharanteB ThilaganathanF PrefumoB ArabinC M BilardoC BrezinkaJ B DerksA DiemertJ J DuvekotE FerrazziT FruscaK HecherN MarlowP MartinelliE OstermayerA T PapageorghiouD SchlembachK T M SchneiderT TodrosA ValcamonicoG H A VisserA Van Wassenaer-LeemhuisChristoph C LeesH Wolfnull nullPublished in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2017)
In accordance with the findings of the TRUFFLE study on monitoring and intervention management of very preterm FGR, we found that the proportion of infants surviving without neuroimpairment was not significantly different when the decision for delivery was based on changes in DV waveform vs reduced STV on CTG. The uneven distribution of fetal deaths towards the DV groups was probably a chance effect, and neurological outcome was better among surviving children in these groups. Before 32 weeks, delaying delivery until abnormalities in DV-PI or STV and/or recurrent decelerations in fetal heat rate occur, as defined by the study protocol, is likely to be safe and possibly benefits long-term outcome. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.