A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression.

Published in: Chemical communications (Cambridge, England) (2023)

We identify and characterize an RNA G-quadruplex (rG4) structure motif in the human microRNA 638 (hsa-miR-638). We investigate the formation and role of this rG4 in vitro and in cells, and reveal that it inhibits the miR-638 and MEF2C messenger RNA interaction and controls gene expression at the translational level.

Keyphrases

gene expression
cell proliferation
long non coding rna
dna methylation
long noncoding rna
endothelial cells
induced apoptosis
nucleic acid
cell cycle arrest
induced pluripotent stem cells
signaling pathway
oxidative stress
pi k akt
pluripotent stem cells