Licochalcone A protects against LPS-induced inflammation and acute lung injury by directly binding with MD2.
Weiwei ZhuMinxiu WangLeiming JinBin YangBin BaiRumbidzai Natasha MutsinzeWei ZuoSiriporn C ChattipakornJoo Young HuhGuang LiangYi WangPublished in: British journal of pharmacology (2022)
In summary, our study identified MD2 as a direct target of LA for its anti-inflammatory activity and suggested that LA might serve as a novel MD2 inhibitor and a potential drug for developing ALI/ARDS therapy.
Keyphrases
- lps induced
- molecular dynamics
- inflammatory response
- liver failure
- oxidative stress
- drug induced
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- respiratory failure
- mechanical ventilation
- stem cells
- emergency department
- intensive care unit
- mesenchymal stem cells
- risk assessment
- aortic dissection
- dna binding
- human health
- adverse drug
- hepatitis b virus
- smoking cessation