Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy.

Frehiwet T HailuAnis Karimpour-FardLee S ToniMichael R BristowShelley D MiyamotoBrian L StaufferCarmen C Sucharov

Published in: Pediatric research (2021)

This is the first study to compare miRNA expression in the heart of pediatric DCM patients to age-matched healthy controls by RNA sequencing. Expression of a subset of miRNAs is uniquely dysregulated in children. Using mRNA-seq and miRNA-seq from matched samples, target prediction was performed. This study underscores the importance of pediatric-focused studies.

Keyphrases

poor prognosis
single cell
end stage renal disease
binding protein
heart failure
chronic kidney disease
genome wide
ejection fraction
newly diagnosed
atrial fibrillation
patient reported outcomes