Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds.
Yanli WangYan LiuYongle WangPing BaiMadelyn Rose HalliseyBreanna Lizeth VarelaAnne SiewkoChangning WangYulong XuPublished in: Drug design, development and therapy (2024)
provides a valuable tool for noninvasive imaging investigations in rodent models with aberrant sirtuin 1 expression. This novel radiotracer holds promise for advancing our understanding of sirtuin 1's role in disease mechanisms and may facilitate the validation of sirtuin 1 inhibitors in clinical trials.