Targeting nicotinamide N-methyltransferase decreased aggressiveness of osteosarcoma cells.
E N SerritelliD SartiniR CampagnaValentina PozziN I MartinM J van HarenE SalvoliniM CecatiC RubiniM EmanuelliPublished in: European journal of clinical investigation (2024)
Results showed that OS samples display a significantly higher NNMT expression compared with healthy tissue. Preliminary results suggest that NNMT silencing in OS cell lines is associated to a decrease of cell proliferation and migration, as well as to enhanced sensitivity to chemotherapy. Data obtained showed that NNMT may represent an interesting marker for OS detection and a promising target for effective anti-cancer therapy.
Keyphrases
- cancer therapy
- drug delivery
- induced apoptosis
- poor prognosis
- single cell
- cell cycle arrest
- cell therapy
- electronic health record
- big data
- loop mediated isothermal amplification
- locally advanced
- oxidative stress
- stem cells
- squamous cell carcinoma
- real time pcr
- label free
- long non coding rna
- machine learning
- radiation therapy
- artificial intelligence
- deep learning
- pi k akt
- chemotherapy induced