Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells.

Neel MehtaDan ZhangRenzhong LiTony WangAgata GavaPavithra ParthasarathyBo GaoJoan C Krepinsky

Published in: Cell communication and signaling : CCS (2019)

These findings shed light on the transcriptional mechanism by which cav-1 represses the expression of a major antifibrotic protein, and can inform the development of novel antifibrotic treatment strategies.

Keyphrases

pulmonary fibrosis
induced apoptosis
binding protein
poor prognosis
protein protein
gene expression
cell cycle arrest
amino acid
transcription factor
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
pi k akt