Manipulation of osteogenic and adipogenic differentiation of human degenerative disc and ligamentum flavum derived progenitor cells using IL-1β, IL-19, and IL-20.

Yu-Hsiang HsuCheng-Nan ChenHsin-I ChangHui-Ling TsaiYu-Hsien ChangI-Szu ChengYu-Shiuan YangKuo-Yuan Huang

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)

IL-1β, IL-19, and IL-20 impact the adipogenic and osteogenic differentiation of IVD-derived and LF-derived cells. Modulating the expression of IL-1β, IL-19, and IL-20 provides a potential avenue for controlling cell differentiation of IVD- and LF-derived cells, which might have beneficial effect for degenerative spondylolisthesis and spinal stenosis.

Keyphrases

induced apoptosis
endothelial cells
mesenchymal stem cells
spinal cord
poor prognosis
bone marrow
spinal cord injury
cell proliferation
cell death
long non coding rna
risk assessment
cell cycle arrest
climate change
induced pluripotent stem cells