Acute and Chronic Neural and Glial Response to Mild Traumatic Brain Injury in the Hippocampus.

brain slices while simultaneously recording glutamatergic inputs onto CA1 hippocampal pyramidal neurons. Post-injury examination of chronic tissue regeneration by astrocytes allow us to connect acute neuronal signaling responses to chronic fibrosis after TBI. These studies provide a new tool for understanding the physiological and molecular responses to TBI and lay the groundwork for future experiments unraveling the synaptic mechanisms that mediate these responses seconds, minutes, and days following injury.