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TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis.

C Appleby-MallinderE SchaberJanine KirbyP J ShawJ Cooper-KnockP R HeathJ Robin Highley
Published in: Neuropathology and applied neurobiology (2020)
DNA methylation is a contributory factor in ALS LMN pathology. This is not so for glia or neocortical neurones.
Keyphrases
  • amyotrophic lateral sclerosis
  • dna methylation
  • genome wide
  • endothelial cells
  • gene expression
  • induced pluripotent stem cells
  • pluripotent stem cells
  • copy number