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Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross-sectional study.

Chuanli YuCongcong DingLihua HuYumeng ShiPeixu ZhaoJin E LiuLiting ZhangDan SunWei ZhouChao YuTao WangLingjuan ZhuXiao HuangHuihui BaoXiaoshu Cheng
Published in: Journal of clinical hypertension (Greenwich, Conn.) (2024)
Increased plasma homocysteine (Hcy) has been identified as one of the important risk factors for cardiovascular disease. However, the association between plasma Hcy and peripheral artery disease (PAD) is still controversial. This study aimed to investigate the association between plasma Hcy and PAD and the potential modifier factors in Chinese hypertensive adults. A total of 25 300 hypertensive patients aged 18 years or older were included in the analysis in this cross-sectional study. The outcome was PAD, which defined as an ankle-brachial index ≤0.90 in either limb. Multiple logistic regression was used to analyze the relationship between plasma Hcy and PAD. The median plasma Hcy was 14.00 (interquartile range: 11.60-17.80) μmol/L. There was a significant positive association between plasma Hcy and PAD (per SD increment; OR: 1.13; 95% CI: 1.06-1.19). Patients in the upper plasma Hcy tertile (≥16.16 μmol/L) were associated with a 53% increased risk of PAD compared with patients in the lower tertile (<12.33 μmol/L) after adjustment for multiple potential confounders. Subgroup analyses showed the association between Hcy and PAD was robust among various strata. Among Chinese adults with hypertension, plasma Hcy is an independent risk factor for PAD. This finding may improve the risk stratification of PAD.
Keyphrases
  • blood pressure
  • cardiovascular disease
  • hypertensive patients
  • peripheral artery disease
  • randomized controlled trial
  • physical activity
  • clinical trial
  • coronary artery disease
  • open label