Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.

Eloi R VerrierGaetan LigatLaura HeydmannKatharina DoernbrackJulija MillerAnne Maglott-RothFrank JühlingHoussein El SaghireMargaux J HeuschkelNaoto FujiwaraSen-Yung HsiehYujin HoshidaDavid E RootEmanuele FelliPatrick PessauxAtish MukherjiLaurent MaillyCatherine SchusterLaurent BrinoMichael Nassal Thomas F Baumert

Published in: Gut (2022)

Our cell-based reporter assay enables the discovery of HBV cccDNA host factors including YBX1 and is suitable for the characterisation of cccDNA-related host factors, antiviral targets and compounds.

Keyphrases

single cell
high throughput
hepatitis b virus
crispr cas
cell therapy
small molecule
liver failure
genome wide
gene expression
bone marrow
drug induced