Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.
Shodai MizunoRyo SeishimaJuntaro YamasakiKaoru HattoriMasayo OgiriShimpei MatsuiKohei ShigetaKoji OkabayashiOsamu NaganoLiang LiYuko KitagawaPublished in: Journal of cancer research and clinical oncology (2022)
ANGPTL4 regulates the expression of GLUTs by activating the PI3K-AKT pathway and thereby promoting glucose metabolism in CRC. These findings establish a new functional role of ANGPTL4 in cancer progression and lay the foundation for developing a novel therapeutic target.