FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression.

Jifen HuJian GaoChunlin WangWuling LiuAnling HuXiao XiaoYi KuangKunlin YuBabu GajendranEldad ZacksenhausWeidong PanYaacov Ben-David

Published in: Journal of inflammation research (2023)

These results suggest a role for the transcription factor FLI1 in inflammation signaling and leukemia progression through HDC and point to the HDC pathway as potential therapeutics for FLI1-driven leukemia.

Keyphrases

acute myeloid leukemia
bone marrow
oxidative stress
transcription factor
poor prognosis
small molecule
human health
climate change