Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: a machine learning approach using clinical trial data.
Stephanie Q DuongCynthia S CrowsonArjun AthreyaElizabeth J AtkinsonJohn M DavisKenneth J WarringtonEric L MattesonRichard WeinshilboumLiewei WangElena MyasoedovaPublished in: Arthritis research & therapy (2022)
We have developed and externally validated a prediction model for response to methotrexate within 24 weeks in DMARD-naïve patients with RA, providing variably weighted clinical features and defined cutoffs for clinical decision-making.