[Sivelestat sodium inhibits neutrophil elastase to regulate intrahepatic biliary mucin 5AC expression].

Ximao GuHaijun YeChenglei XuZhuying LinJiang Li

Published in: Zhonghua wei zhong bing ji jiu yi xue (2024)

LPS can upregulate the expression of NE and MUC5AC in rats with cholangitis, while sodium sivelestat can reduce the expression of MUC5AC in in intrahepatic biliary epithelial cells by inhibiting NE, providing a new direction for the treatment of IBDS.

Keyphrases

poor prognosis
binding protein
inflammatory response
anti inflammatory
replacement therapy