Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review.
Emilyn Costa ConceiçãoRichard Steiner SalvatoKaren Machado GomesArthur Emil Dos Santos GuimarãesMarília Lima da ConceiçãoRicardo José de Paula Souza E GuimarãesAbhinav SharmaIsmari Perini FurlanetoRegina Bones BarcellosValdes Roberto BollelaLívia Maria Pala AnselmoMaria Carolina SiscoCristina Viana NieroLucilaine FerrazoliGuislaine RefrégierMaria Cristina da Silva LourençoHarrison Magdinier GomesArtemir Coelho de BritoMarcos CatanhoRafael Silva DuartePhilip Noel SuffysKarla Valéria Batista LimaPublished in: Memorias do Instituto Oswaldo Cruz (2021)
Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.
Keyphrases
- mycobacterium tuberculosis
- genetic diversity
- multidrug resistant
- case report
- pulmonary tuberculosis
- genome wide
- public health
- climate change
- drug resistant
- high frequency
- acinetobacter baumannii
- gram negative
- single cell
- high throughput
- dna methylation
- emergency department
- adverse drug
- escherichia coli
- genome wide association study
- randomized controlled trial
- case control
- rna seq
- genome wide association