Login / Signup

Visible-Light Induced Radical Perfluoroalkylation/Cyclization Strategy To Access 2-Perfluoroalkylbenzothiazoles/Benzoselenazoles by EDA Complex.

Yan LiuXiao-Lan ChenXiao-Lan ChenXiao-Yun LiFan-Lin ZengXiao-Ceng LiuLing-Bo QuYu-Fen ZhaoBing Yu
Published in: Organic letters (2019)
A novel and practical fluoroalkyl radical-initiated cascade reaction was developed to access diverse 2-fluoroalkylbenzothiazoles by reacting various fluoroalkyl radical sources, including perfluoroalkyl iodide (IC nF2 n+1, n = 3-8, 10), ICF(CF3)2, ICF2COOEt, ICF2CF2Cl, or ICF2CF2Br, tetramethylethane-1,2-diamine (TMEDA), and 2-isocyanoaryl thioethers in tetrahydrofuran under nitrogen atmosphere and blue-light irradiation conditions. Furthermore, this one-pot protocol could well be expanded to access various 2-fluoroalkylbenzoselenazoles starting from (2-isocyanophenyl)(methyl)selane, perfluoroalkyl iodides (IC nF2 n+1, n = 3-8) or ICF2COOEt and TMEDA.
Keyphrases
  • cystic fibrosis
  • signaling pathway
  • visible light
  • lps induced
  • oxidative stress
  • randomized controlled trial
  • pi k akt
  • nuclear factor
  • drinking water
  • immune response
  • amino acid