Chemodivergent Synthesis of Allylic Sulfones via Ligand-Controlled Coupling of Allenes with Sulfinic Acids.

Allylic sulfones are important building blocks in organic synthesis and pharmaceutical chemistry. Herein, we disclose a chemodivergent protocol for Pd-catalyzed and ligand-controlled coupling of allenes with sulfinic acids, providing straightforward and atom-economical access to branched allylic sulfones and linear allylic sulfones bearing a conjugated ( Z,E )-1,3-diene scaffold in good yields with high selectivities. This strategy features mild conditions, an unprecedented substrate scope, and functional group compatibility.