Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.

Vincent Kam Wai WongCongling QiuSu-Wei XuBetty Yuen Kwan LawWu ZengHui WangFrancesco MichelangeliIvo Ricardo De Seabra Rodrigues DiasYuan Qing QuTsz Wai ChanYu HanNi ZhangSimon Wing Fai MokXi ChenLu YuHudan PanSami HamdounThomas EfferthWen Jing YuWei ZhangZheng LiYuesheng XieRiqiang LuoQuan JiangLiang Liu

Published in: British journal of pharmacology (2019)

Celastrol triggered Ca2+ signalling to induce autophagic cell death in RASFs/RAFLS and ameliorated arthritis in AIA rats mediated by calcium-dependent/-binding proteins facilitating the exploitation of anti-arthritic drugs based on manipulation of Ca2+ signalling.

Keyphrases

cell death
rheumatoid arthritis patients
rheumatoid arthritis
disease activity
protein kinase
systemic lupus erythematosus
cell proliferation
pi k akt