Myelodysplastic syndromes disable human CD271 + VCAM1 + CD146 + niches supporting normal hematopoietic stem/progenitor cells.

Yuko KawanoHiroki KawanoDalia GhoneimThomas J FountaineDaniel K ByunMark W LaMereJason H MendlerTzuChieh HoNoah A SalamaJason R MyersSiba El HusseinBenjamin J FrischJohn M AshtonMitra AzadnivJane L LiesveldYoumna KfouryDavid T ScaddenMichael W BeckerLaura M Calvi

Published in: bioRxiv : the preprint server for biology (2023)

Subsets of human bone marrow derived mesenchymal stromal cells provide differential support of hematopoietic stem and progenitor cells.MDS-derived CD271+VCAM-1+CD146+ mesenchymal stromal cells lose their ability to support hematopoietic stem and progenitor cells.

Keyphrases

endothelial cells
nk cells
bone marrow
pluripotent stem cells
mesenchymal stem cells
peripheral blood