Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial.
Fouzi BalaMohammed AlmekhlafiNishita SinghIbrahim AlhabliAyoola AdemolaShelagh B CouttsYan DeschaintreHouman KhosravaniRamana AppireddyFrancois MoreauStephen PhillipsGordon GubitzAleksander TkachLuciana CataneseDariush DowlatshahiGeorge MedvedevJennifer L MandziaAleksandra PikulaJai Jai Shiva ShankarHeather WilliamsThalia Shoshana FieldHerbert Alejandro Manosalva AlzateMuzzafar SiddiquiAtif ZafarOje ImoukhoudeGary R HunterFaysal BenaliMacKenzie HornMichael D HillMichel Christopher Frank ShamyTolulope SajobiBrian BuckRichard H SwartzBijoy K MenonAlexandre Y PoppePublished in: International journal of stroke : official journal of the International Stroke Society (2023)
In patients with carotid TL treated with EVT, intravenous tenecteplase may be associated with similar or better clinical outcomes, similar angiographic reperfusion rates and safety outcomes as compared to alteplase.
Keyphrases
- acute ischemic stroke
- cerebral ischemia
- atrial fibrillation
- study protocol
- acute myocardial infarction
- phase iii
- clinical trial
- high dose
- phase ii
- randomized controlled trial
- heart failure
- type diabetes
- blood brain barrier
- subarachnoid hemorrhage
- metabolic syndrome
- newly diagnosed
- coronary artery disease
- adipose tissue
- left ventricular
- percutaneous coronary intervention