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GNAO1 Mutations Affecting the N-Terminal α-Helix of Gαo Lead to Parkinsonism.

Gonzalo P SolisYonika Arum LarasatiMoritz ThielAlexey KovalAnne KoyVladimir L Katanaev
Published in: Movement disorders : official journal of the Movement Disorder Society (2024)
Our study defines a parkinsonism phenotype within the spectrum of GNAO1 disorders and suggests a genotype-phenotype correlation by GNAO1 mutations targeting the N-terminal α-helix of Gαo. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keyphrases
  • parkinson disease
  • drug induced
  • dna binding
  • cancer therapy
  • randomized controlled trial
  • drug delivery