METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma.

Ting LiPei-Shan HuZhixiang ZuoJin-Fei LinXingyang LiQi-Nian WuZhan-Hong ChenZhao-Lei ZengFeng WangJian ZhengDemeng ChenBo LiTie-Bang KangDan XieDongxin LinHuai-Qiang JuRui-Hua Xu

Published in: Molecular cancer (2019)

Overall, our study revealed that METTL3, acting as an oncogene, maintained SOX2 expression through an m6A-IGF2BP2-dependent mechanism in CRC cells, and indicated a potential biomarker panel for prognostic prediction in CRC.

Keyphrases

poor prognosis
binding protein
induced apoptosis
cell cycle arrest
pi k akt
stem cells
single cell
endoplasmic reticulum stress