Fluoroquinolones Suppress TGF-β and PMA-Induced MMP-9 Production in Cancer Cells: Implications in Repurposing Quinolone Antibiotics for Cancer Treatment.

Cheng-Yi HuangJenq-Lin YangJih-Jung ChenShun-Ban TaiYu-Hsuan YehPei-Feng LiuMing-Wei LinChih-Ling ChungChun-Lin Chen

Published in: International journal of molecular sciences (2021)

Overall, we demonstrated that FQs inhibit cancer cell migration and invasion by downregulating MMP-9 expression and revealed the cellular mechanisms underlying their potential value in cancer treatment.

Keyphrases

poor prognosis
cell migration
high glucose
diabetic rats
transforming growth factor
single cell
drug induced
oxidative stress
endothelial cells
human health
epithelial mesenchymal transition
signaling pathway
climate change
risk assessment