Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis.
Darryl LeongFrancisco X GaldosDaniel LeeSarah WalianyYuhsin Vivian HuangJulia RyanKatherine DangJoel W NealHeather A WakeleeSunil A ReddySandy SrinivasLih-Ling LinRonald M WittelesHolden T MaeckerMark M DavisPatricia K NguyenSean M WuPublished in: Circulation (2022)
cells have unique transcriptional changes, including upregulation of chemokines CCL5/CCL4/CCL4L2, which may serve as attractive diagnostic/therapeutic targets for reducing life-threatening cardiac immune-related adverse events in ICI-treated patients with cancer.
Keyphrases
- liver injury
- drug induced
- liver fibrosis
- induced apoptosis
- dna damage
- cell cycle arrest
- high glucose
- gene expression
- diabetic rats
- left ventricular
- signaling pathway
- poor prognosis
- transcription factor
- cell cycle
- oxidative stress
- peripheral blood
- heart failure
- cell death
- endoplasmic reticulum stress
- heat shock
- pi k akt