Impact of combined exercise training on the development of cardiometabolic and neuroimmune complications induced by fructose consumption in hypertensive rats.
Danielle da Silva DiasNathalia BernardesFilipe Fernandes Stoyell-ContiCamila Paixão Dos SantosAmanda Aparecida de AraujoSusana LlesuyMaria Cláudia IrigoyenKátia De AngelisPublished in: PloS one (2020)
This study evaluated the impact of combined exercise training on the development of cardiovascular and neuroimmune complications induced by fructose consumption (10% in the drinking water) in hypertensive rats (SHR). After weaning, SHR were divided into 3 groups: SHR (H), SHR+fructose (HF) and SHR+fructose+combined exercise training (treadmill+ladder, 40-60% of maximum capacity) (HFTC). Metabolic, hemodynamic, autonomic, inflammatory and oxidative stress parameters were evaluated in the subgroups (n = 6 group/time) at 7, 15, 30 and 60 days of protocol. Fructose consumption (H vs. HF groups) decreased spontaneous baroreflex sensitivity and total variance of pulse interval at day 7 (7 to 60); increased IL-6 and TNFα in the heart (at day 15, 30 and 60) and NADPH oxidase activity and cardiac lipoperoxidation (LPO) (day 60); increased white adipose tissue weight, reduced insulin sensitivity and increased triglycerides (day 60); induced an additional increase in mean arterial pressure (MAP) (days 30 and 60). Combined exercise training prevented such dysfunctions and sustained increased cardiac IL-10 (day 7) and glutathione redox balance (GSH/GSSG) for the entire protocol. In conclusion, combined exercise training performed simultaneously with exacerbated fructose consumption prevented early cardiovascular autonomic dysfunction, probably trigging positive changes in inflammation and oxidative stress, resulting in a better cardiometabolic profile in rats genetically predisposed to hypertension.
Keyphrases
- oxidative stress
- skeletal muscle
- drinking water
- adipose tissue
- diabetic rats
- blood pressure
- randomized controlled trial
- dna damage
- ischemia reperfusion injury
- left ventricular
- heart rate variability
- rheumatoid arthritis
- type diabetes
- body mass index
- weight loss
- metabolic syndrome
- induced apoptosis
- atrial fibrillation
- health risk
- weight gain
- high glucose
- mechanical ventilation
- endothelial cells