Insulin-like growth factor binding protein-7 concentrations in chronic heart failure: Results from the EMPEROR programme.

João Pedro FerreiraMilton PackerNaveed SattarJaved ButlerSandra González MaldonadoMarina Panova-NoevaMikhail SuminSerge MassonStuart J PocockStefan D AnkerFaiez ZannadJames L Januzzi

Published in: European journal of heart failure (2024)

Across the entire left ventricular EF spectrum in the EMPEROR Programme, concentrations of the senescence-associated biomarker IGFBP7 were associated with higher risk clinical status and predicted adverse cardio-renal outcomes even in models adjusted for conventional biomarkers. Empagliflozin did not significantly affect IGFBP7 levels over time.

Keyphrases

binding protein
left ventricular
study protocol
heart failure
dna damage
endothelial cells
ejection fraction
aortic stenosis
mitral valve
randomized controlled trial
emergency department
coronary artery disease
adipose tissue
clinical trial
atrial fibrillation
aortic valve
double blind