Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients.

Karin JasekMarian GrendarAndrea StanclovaBibiana MalicherovaIvana KasubovaTatiana BurjanivovaPeter SzepeRachele CiccocioppoLuis RodrigoRobert ProseckyPeter KruzliakLukas PlankZora Lasabova

Published in: Journal of cancer research and clinical oncology (2020)

Our results do not support the association between KIT SNPM541L and increased risk of relapse in localized primary GISTs. Additionally, we found a positive correlation between KIT SNPM541L occurrence and earlier onset of relapse in PDGFRa and WT subgroup of GISTs.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
peritoneal dialysis
risk assessment
prognostic factors
risk factors
randomized controlled trial
clinical trial
patient reported outcomes
study protocol