Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis.

Sicong TuRicarda A L MenkeKevin TalbotMatthew C KiernanMatthew C Kiernan

Published in: Journal of neurology, neurosurgery, and psychiatry (2018)

Regional thalamic connectivity changes mirror the progressive frontotemporal cortical involvement associated with the motor functional decline in ALS. Longitudinal MRI thalamic parcellation has potential as a non-invasive surrogate marker of cortical dysfunction in ALS.

Keyphrases

amyotrophic lateral sclerosis
deep brain stimulation
multiple sclerosis
contrast enhanced
magnetic resonance imaging
diffusion weighted imaging
oxidative stress
resting state
functional connectivity
cross sectional