Ginsenoside Rb1 alleviates lipopolysaccharide-induced inflammation in human dental pulp cells via the PI3K/Akt, NF-κB, and MAPK signalling pathways.
Ok Hyung NamJae-Hwan KimSi Won KangYong Kwon ChaeMyeong-Kwan JihHyekyoung Hannah YouJeong Tae KohYoung KimPublished in: International endodontic journal (2024)
G-Rb1 suppressed the LPS-induced increase of cell adhesion molecules and inflammatory cytokines, while also inhibiting PI3K/Akt, phosphorylation of NF-κB transcription factors, ERK and JNK of MAPK signalling in hDPCs.
Keyphrases
- signaling pathway
- pi k akt
- lps induced
- inflammatory response
- lipopolysaccharide induced
- induced apoptosis
- cell cycle arrest
- cell adhesion
- toll like receptor
- transcription factor
- endothelial cells
- oxidative stress
- induced pluripotent stem cells
- mouse model
- pluripotent stem cells
- endoplasmic reticulum stress
- cell proliferation